JPA : Como gerenciar o EntityManagerFactor e EntityManager?

package br.teste.pacote;

import javax.persistence.EntityManager;
import javax.persistence.EntityManagerFactory;
import javax.persistence.Persistence;
import javax.persistence.Query;

import br.com.jpa.component.ConfigPersistence;
import br.com.jpa.component.Configuration;

public class TestJPA {

        public static void main(String[] args) {
                
                Configuration configuration = ConfigPersistence.getInstanceConfiguration();
                
                EntityManagerFactory factory = configuration.createEntityManagerFactory();

                EntityManager em = factory.createEntityManager();
                
                Query query = em.createQuery("SELECT e FROM Cliente e ");

                List<Cliente> clientes = (List<Cliente>)query.getResultList();
                
                for(Cliente cliente : clientes) {

                        System.out.println(cliente.getNome());

                }
        }
}

<?xml version="1.0" encoding="UTF-8"?>
<beans xmlns="http://www.springframework.org/schema/beans"
	xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
	xmlns:context="http://www.springframework.org/schema/context"
	xmlns:aop="http://www.springframework.org/schema/aop"
	xmlns:tx="http://www.springframework.org/schema/tx"
	xsi:schemaLocation="http://www.springframework.org/schema/beans 
						http://www.springframework.org/schema/beans/spring-beans-3.0.xsd 
						http://www.springframework.org/schema/context 
						http://www.springframework.org/schema/context/spring-context-3.0.xsd 
						http://www.springframework.org/schema/tx 
						http://www.springframework.org/schema/tx/spring-tx-3.0.xsd 
						http://www.springframework.org/schema/aop 
						http://www.springframework.org/schema/aop/spring-aop-3.0.xsd">
							
	<!-- ********************************************* -->
	<!-- Configuração do DataSource -->
	<!-- ********************************************* -->
	 
    <bean id="dataSource"
		class="com.mchange.v2.c3p0.ComboPooledDataSource"
		destroy-method="close">
		<!-- Postgres configutarion -->
		<property name="driverClass" value="com.mysql.jdbc.Driver" />
		<property name="jdbcUrl" value="jdbc:mysql://localhost:3306/db_agenda" />
    	<property name="user" value="root" />
		<property name="password" value="123456" />
	</bean>
    
	<!-- Configuraçãoes relativas a acesso a dados -->
	<bean id="entityManagerFactory"
		class="org.springframework.orm.jpa.LocalContainerEntityManagerFactoryBean">

		<property name="dataSource" ref="dataSource"/>
		
		<property name="jpaDialect">
			<bean class="org.springframework.orm.jpa.vendor.HibernateJpaDialect"></bean>
		</property>
		<property name="jpaVendorAdapter">
			<bean
				class="org.springframework.orm.jpa.vendor.HibernateJpaVendorAdapter">
				<property name="showSql" value="true" />
				<property name="databasePlatform" value="org.hibernate.dialect.MySQL5InnoDBDialect" />
			</bean>
		</property>
		<property name="jpaProperties">
			<props>
				<prop key="hibernate.format_sql">true</prop>
				<prop key="hibernate.query.substitutions">true 'S',false 'N',yes 'S',no 'N'</prop>
				<prop key="hibernate.query.jpaql_strict_compliance">true</prop>
				<prop key="hibernate.hbm2ddl.auto">update</prop> <!-- create | create-drop | validate | update -->
			</props>
		</property>
	</bean>
	
	<!-- Transaction Manager exclusivo para JPA -->
	<bean id="transactionManager"
		class="org.springframework.orm.jpa.JpaTransactionManager">
		<property name="entityManagerFactory" ref="entityManagerFactory"/>
		<property name="jpaDialect">
			<bean class="org.springframework.orm.jpa.vendor.HibernateJpaDialect"></bean>
		</property>
	</bean>
	
</beans>

<?xml version="1.0" encoding="UTF-8"?>
<beans xmlns="http://www.springframework.org/schema/beans"
	xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
	xmlns:context="http://www.springframework.org/schema/context"
	xmlns:aop="http://www.springframework.org/schema/aop"
	xmlns:tx="http://www.springframework.org/schema/tx"
	xsi:schemaLocation="http://www.springframework.org/schema/beans 
						http://www.springframework.org/schema/beans/spring-beans-3.0.xsd 
						http://www.springframework.org/schema/context 
						http://www.springframework.org/schema/context/spring-context-3.0.xsd 
						http://www.springframework.org/schema/tx 
						http://www.springframework.org/schema/tx/spring-tx-3.0.xsd 
						http://www.springframework.org/schema/aop 
						http://www.springframework.org/schema/aop/spring-aop-3.0.xsd">

	<context:annotation-config />
	<context:component-scan base-package="br.com.exemplospring" />
	
	<!-- habilita suporte as anotações transacionais -->
	<tx:annotation-driven order="1" />
	
	<!-- the transactional advice (what 'happens'; see the <aop:advisor/> bean below) -->
	<tx:advice id="txAdvice">
		<!-- the transactional semantics... -->
		<tx:attributes>
			<!-- all methods starting with 'get' are read-only -->
			<tx:method name="find*" read-only="true" />
			<tx:method name="count*" read-only="true" />
			<tx:method name="get*" read-only="true" />
			<tx:method name="busca*" read-only="true" />
			<tx:method name="lista*" read-only="true" />
			<tx:method name="carrega*" read-only="true" />
			<!-- other methods use the default transaction settings (see below) -->
			<tx:method name="*" propagation="REQUIRED" />
		</tx:attributes>
	</tx:advice>
	
	<!-- Configuração do Aspecto das transações. -->
	<aop:config>
		<aop:pointcut id="serviceMethods"
			expression="execution(* br.com.exemplospring.service..*.*(..))" />
		<aop:advisor order="2" advice-ref="txAdvice"
			pointcut-ref="serviceMethods" />
	</aop:config>
	
</beans>